Novoic

Novoic is a company specializing in AI-enabled software designed to detect subtle cognitive impairment and Alzheimer’s neuropathology based on speech. Their flagship product, AccuRater™, is an AI-based system that fully automates the rating and review of clinical assessments in CNS trials. Novoic’s technology supports early detection of Alzheimer’s disease in underserved communities, operating across more than 50 medical centers. Their audio-verbal assessments are fully automated and have been tested on thousands of users, offering a low-burden, high-usability solution for elderly and cognitively impaired populations. The browser-based approach allows use on any smart device, ensuring accessibility and convenience. High data integrity is maintained through built-in quality control systems, audio standardization, and automated speech recognition. Novoic’s models accurately detect mild cognitive impairment, including subthreshold impairment in preclinical Alzheimer’s disease, and their speech-based tests are the first to predict amyloid PET positivity with performance comparable to plasma tests. The company designs and trains large audio and language models in-house using proprietary methods and datasets. Clinical trials in biomarker-confirmed prodromal and preclinical Alzheimer’s have enhanced the predictive, robust, and equitable nature of their algorithms. Real-world datasets from diverse communities further improve robustness to demographic variance. Automated assessments and rapid analysis outputs aid in patient selection across over 50 medical centers in the US. Novoic’s dashboard facilitates digital screening and monitoring at scale, featuring AI-assisted triage and built-in analytics. Their solutions offer flexible integration with SDKs and hosted versions for large multi-site trials. Integrated HIPAA/GDPR compliance and automated backups ensure data privacy and integrity, while gold-standard security protocols protect against cyber risks. Additionally, Novoic has developed a custom clinical transcription model for high-quality, segmented transcripts of audio recordings. AccuRater™ has demonstrated performance at or above the level of trained human raters in rating common performance-based outcome assessments and can be deployed for most existing clinical assessments with broad language availability and HIPAA compliance.