Alice Refermat

Alice Refermat serves as the Director of the Center for CRISPR Target Discovery. Her notable career includes significant contributions to CRISPR technology at Memorial Sloan Kettering Cancer Center, where she focused on CRISPR cell-line engineering and the construction of CRISPR libraries. She led the development of a barcoded CRISPR library targeting the ‘druggable’ genome and conducted several whole-genome CRISPR screens to identify new gene targets that affect drug sensitivity in lymphoma cell lines. Additionally, Refermat co-invented ZFPOFF, a platform technology for heritable epigenetic gene repression using artificial zinc-finger proteins. She is currently exploring the application of ZFPOFF technology to develop treatments for KRAS-based cancers, demonstrating her ongoing commitment to advancing cancer therapeutics.