Origami Therapeutics, Inc.

Origami Therapeutics, Inc. Employees

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Origami Therapeutics, Inc. Company Information

Origami Therapeutics, Inc. is a healthcare company located in San Diego, CA, USA, specializing in the development of therapeutics for neurodegenerative diseases. With a team of four, the company operates within the therapeutics sub-industry and is part of the Y Combinator W22 batch. Origami Therapeutics has garnered attention in media outlets for its innovative approach to treating neurodegenerative diseases and has participated in several industry conferences and showcases, including the 17th Annual Huntington’s Disease Therapeutics Conference, the 10th Annual Neurodegenerative Drug Development Summit, and the Demy Colton BioFuture Conference. The company has also been featured in BioCentury and MedCity News articles, and participated in panels at events such as the RESI Digital: Investing in Precision Medicine and the BioTech Showcase 2022- Rare Disease: The Value Proposition Keeps Expanding. CEO Beth Hoffman serves on the Huntington’s Disease Society of America (HDSA) National Board of Trustees, and the company was listed as one of BioCentury’s 2021 Class of Emerging Companies. Origami Therapeutics is developing next-generation disease-modifying protein degraders and correctors, focusing on oral drugs that target and degrade disease-related proteins to delay or halt disease progression. Their first indication is Huntington’s disease, where they have identified small molecules that reduce the toxic mutated protein and suppress mutant protein-induced toxicities in human disease neurons. The company anticipates that its approach will be broadly applicable to traditionally “undruggable” targets in other neurological diseases.

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