One Codex

One Codex, located in San Francisco, CA, operates within the healthcare industry, specifically in the Healthcare IT sub-sector. The company, which participated in Y-Combinator’s S14 batch, employs a team of 16 professionals. One Codex offers specialized microbiome sequencing and analysis services, particularly optimized for the gut microbiome. Their services include shotgun sequencing for microbiome samples, with results delivered in as little as 4 weeks, and the provision of sample kits that ensure reproducibility and traceability from lab to analysis results. The company uses a fully automated DNA extraction process optimized for capturing microbial diversity and employs a library preparation method that minimizes GC bias and uses unique dual indexed (UDI) adapters for accurate sample assignment. Libraries are sequenced to a depth of 2 million 2x150 bp read pairs to achieve species and strain level taxonomic resolution. Sequencing data are automatically uploaded for analysis against the One Codex Database, which contains over 115k whole microbial reference genomes. This database serves as a comprehensive microbial genomics reference for the accurate analysis of complex metagenomic samples. Additionally, One Codex provides a cloud-based analytical platform for microbial genomics that supports regulatory and compliance requirements, including GxP and HIPAA. This platform integrates capabilities for sequencing, analysis, health record data tracking, interactive visualization, and interpretation for genomic healthcare epidemiology. The company also offers a Genome Library for microbial genomics, which simplifies microbial genomics by providing one-click assembly, user-friendly genome annotation browsing, and real-time querying of genomic sequences. Moreover, One Codex has developed a data platform for microbiome discovery and characterization, designed to accelerate microbiome discovery workflows and ensure reproducibility in clinical trials. This platform also allows for the secure sharing and collaboration of microbiome data, controlling access while enabling independent research by team members.